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Impact of pharmaceutical care on clinical outcomes among hemodialysis patients: A multicenter randomized controlled

Uday Venkat Mateti1, Anantha Naik Nagappa2, Ravindra Prabhu Attur3

  • 1Department of Pharmacy Management, Manipal College of Pharmaceutical Sciences, MAHE, Manipal; Department of Pharmacy Practice, Nitte Gulabi Shetty Memorial Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Mangaluru, India.

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
|August 29, 2018
PubMed

Insights

Pharmaceutical care significantly improved medication adherence and health outcomes for hemodialysis patients. This intervention positively impacted hemoglobin levels, blood pressure, and reduced interdialytic weight gain.

Area of Science:

  • Nephrology
  • Clinical Pharmacy
  • Patient Care

Background:

  • Hemodialysis patients often face challenges with medication adherence and managing key health indicators.
  • Poor management of hemoglobin (Hb) levels, blood pressure (BP), and interdialytic weight gain (IDW) can lead to adverse outcomes in hemodialysis patients.

Purpose of the Study:

  • To evaluate the effect of pharmaceutical care on medication adherence, Hb levels, BP, and IDW in hemodialysis patients.
  • To compare the outcomes of pharmaceutical care versus usual care in a hemodialysis population.

Main Methods:

  • An open-label, randomized controlled study involving 153 hemodialysis patients across three hospital types.
  • Patients were assigned to either a usual care group (UCG) or a pharmaceutical care group (PCG) and assessed at baseline, 6, and 12 months.
  • Pharmaceutical care involved patient education on disease, medications, lifestyle, nutrition, and medication review by a pharmacist.

Main Results:

  • The pharmaceutical care group (PCG) demonstrated significant reductions in interdialytic weight gain (IDW) and blood pressure (BP) compared to the usual care group (UCG) (P <0.05).
  • Hemodialysis patients in the PCG showed significant improvements in hemoglobin (Hb) levels and medication adherence rates compared to the UCG.
  • The WHO-ICF pharmaceutical care model positively influenced medication adherence, Hb levels, BP, and IDW.

Conclusions:

  • Implementing a structured pharmaceutical care model significantly enhances medication adherence and clinical outcomes in hemodialysis patients.
  • Pharmaceutical care is an effective strategy for managing key health parameters like Hb levels, BP, and IDW in hemodialysis patients.
  • Registered pharmacists play a crucial role in improving patient outcomes through comprehensive pharmaceutical care.

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