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Published on: August 28, 2018
Increased glycoprotein acetylation is associated with high cardiac event rates: Analysis using coronary computed
Lihua An, Qingxu Liu, Haixia Feng
1Department of Radiology, The Affiliated Hospital of Jining Medical University; Shandong-China. lijingmeical@163.com.
Insights
High glycoprotein acetylation (GlycA) levels indicate increased risk for coronary artery disease (CAD) and major adverse cardiac events (MACE) in patients undergoing CCTA. This inflammatory biomarker is linked to worse long-term outcomes.
Area of Science:
- Biomarkers
- Cardiovascular Disease
- Inflammation
Background:
- Glycoprotein acetylation (GlycA) is an emerging inflammatory biomarker.
- GlycA has been utilized as an indicator for cardiovascular disease.
- The association between GlycA and coronary artery disease (CAD) requires further investigation.
Purpose of the Study:
- To evaluate the correlation between GlycA and CAD.
- To assess the predictive value of GlycA for major adverse cardiac events (MACE) in patients undergoing CCTA.
Main Methods:
- 342 patients underwent coronary computed tomography angiography (CCTA).
- Cox's proportional hazards models were used to analyze the correlation between GlycA and MACE.
- Patients were stratified into three groups based on GlycA levels (T1, T2, T3).
Main Results:
- Higher GlycA levels (T3) were associated with increased atherosclerotic plaque, obstructive CAD risk, and MACE.
- Elevated GlycA levels correlated with higher all-cause mortality compared to lower levels (T1).
- In patients without CAD, high GlycA levels indicated heightened atherosclerotic stress and MACE risk.
Conclusions:
- Serum GlycA is significantly associated with long-term clinical outcomes in patients undergoing CCTA.
- High GlycA levels predict increased risks of MACE and mortality, even in individuals without known CAD.
Objective:
Glycoprotein acetylation (GlycA), an emerging inflammatory biomarker, has been used as an indicator of cardiovascular disease. Our research aimed to evaluate the correlation between GlycA and coronary artery disease (CAD) using coronary computed tomography angiography (CCTA).
Methods:
In the present study, a total of 342 patients were enrolled, and each of them underwent CCTA. The correlation between GlycA and major adverse cardiac events (MACE) was detected via Cox's proportional hazards models. Based on differences in the GlycA level, patients were categorized into three groups (T1, T2, and T3).
Results:
Compared with the group with the lowest GlycA level (T1), the group with the highest GlycA level (T3) exhibited stronger atherosclerotic pressure involving the extent of atherosclerotic plaque and risk of obstructive CAD. In addition, the patients in the T3 group had a greater chance of experiencing MACE and higher all-cause mortality than those in the T1 group. Among patients without CAD who underwent CCTA, those with high GlycA levels experienced elevated atherosclerotic stress and heightened risk of MACE compared with those with low GlycA levels.
Conclusion:
These results suggest that serum GlycA is significantly associated with the long-term clinical results of patients with no known CAD undergoing CCTA. The risks of death and experiencing MACE increase among patients with high GlycA levels.
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