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Published on: August 23, 2018
Construction of Crowning β-cyclodextrin with Temperature Response and Efficient Properties of Host-Guest Inclusion
Dongmei Zhang1, Cheng Yang1, Ziru Niu2
1The Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering , Jiangnan University , Wuxi 214122 , China.
Abstract:
Promoting a drug inclusion proportion in hydrophobic cavity of β-cyclodextrin using simple methods is a highly ambitious task. Herein, we report the crowning β-cyclodextrins formed by intramolecular hydrogen bonding interaction, which has greatly prolonged the cavity depth of β-cyclodextrin, and therefore further efficiently improved the inclusion proportion to complex drug molecule (vitamin E). Furthermore, the self-assembly behaviors, controllable release, and antioxidant properties of vitamin E embedded into the cavity of crowning β-cyclodextrins was investigated, and host-guest inclusions exhibited temperature-responsive controlled release, excellent antioxidant activity, and photostability.
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