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Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain
Published on: August 8, 2019
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Clodronate improves lameness in horses without changing bone turnover markers
A Mitchell1, G Wright2, S N Sampson1
1Department of Large Animal Clinical Sciences, Cornell University, Ithaca, New York, USA.
Equine Veterinary Journal
|August 29, 2018
Summary
A single dose of clodronate reduced lameness and improved performance in horses. Further research is needed to understand the long-term effects of bisphosphonate drugs on bone remodelling and lameness.
Area of Science:
- Equine Sports Medicine
- Pharmacology
- Veterinary Orthopedics
Background:
- Clodronate is widely used for equine lameness, but its effects are not well-researched.
- Limited data exists on clodronate's impact on bone remodeling and cell recruitment in horses.
Purpose of the Study:
- To evaluate the effects of a single dose of clodronate on bone remodeling, cell recruitment, and lameness in horses.
- To assess changes in bone turnover markers (CTX-I, osteocalcin) and lameness scores post-treatment.
Main Methods:
- A blinded, randomized study involving 12 horses with navicular syndrome.
- Horses received either clodronate (1.4 mg/kg) or a placebo (LRS).
- Bone turnover markers, lameness, and performance were assessed over 8 weeks; in vitro bone cell recruitment was also evaluated.
Main Results:
- No significant differences in bone cell recruitment or bone turnover markers (CTX-I, osteocalcin) were observed.
- A significant decrease in forelimb lameness was noted one week after clodronate administration.
- Coaches reported significantly improved performance in clodronate-treated horses at 8 weeks.
Conclusions:
- Single-dose clodronate effectively reduced lameness and improved performance in horses without altering bone turnover markers.
- Potential confounding factors included anti-inflammatory medication in control horses.
- Further investigation into the effects of repeated bisphosphonate dosing is warranted.
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