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Updated: Aug 10, 2026

Live Imaging Of Drosophila melanogaster Embryonic Hemocyte Migrations
Published on: February 13, 2010
"A narrow bridge home": The dorsal mesentery in primordial germ cell migration
Gideon Hen1, Dalit Sela-Donenfeld1
1Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.
Abstract:
Specification of primordial germ cells (PGCs) in all vertebrates takes place in extragonadal sites. This requires migration of PGCs through embryonic tissues towards the genital ridges by both passive and active types of migration. Commonly, colonization in the genital ridges follows migration of the PGCs along the thin tissue of the dorsal mesentery. Here we review the anatomy of the dorsal mesentery, the role it plays in migration of PGCs, and the interactions of PGCs with different cell types, extracellular matrix and signaling pathways that are all essential for attraction and orientation of PGCs along the dorsal mesentery towards the gonad anlage.
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