Bioavailability of coenzyme Q10 supplements depends on carrier lipids and solubilization

Bioavailability of supplements with coenzyme Q10 (CoQ₁₀) in humans seems to depend on the excipients of formulations and on physiological characteristics of the individuals. The aim of this study was to determine which factors presented in CoQ₁₀ supplements affect the different response to CoQ₁₀ in humans.

We tested seven different supplement formulations containing 100 mg of CoQ₁₀ in 14 young, healthy individuals. Bioavailability was measured as area under the curve of plasma CoQ₁₀ levels over 48 h after ingestion of a single dose. Measurements were repeated in the same group of 14 volunteers in a double-blind crossover design with a minimum of 4 wk washout between intakes.

Bioavailability of the formulations showed large differences that were statistically significant. The two best absorbable formulations were soft-gel capsules containing ubiquinone (oxidized CoQ₁₀) or ubiquinol (reduced CoQ₁₀). The matrix used to dissolve CoQ₁₀ and the proportion and addition of preservatives such as vitamin C affected the bioavailability of CoQ₁₀. Although control measurements documented that all formulations contained 100 mg of either CoQ₁₀ or ubiquinol, some of the participants showed high and others lower capacity to reach high increase of CoQ₁₀ in blood, indicating the participation of individual unknown physiological factors.

This study highlights the importance of individually adapted selection of best formulations to reach the highest bioavailability of CoQ₁₀ in humans.