Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Ribosome Profiling

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...

Taping Over Different Ground Profiles

Taping Over Different Ground Profiles

Taping over varying ground profiles requires careful adaptation to achieve accurate measurements. On smooth, level ground with minimal vegetation, the tape can rest directly on the ground. Here, the taping team, typically consisting of a head and a rear tapeman, coordinates their positions with clear communication. The rear tapeman holds the tape at the starting point and guides the head tapeman toward a range pole placed beyond the endpoint, using hand or voice signals to ensure alignment.On...

Profile Leveling and Cross Sections

Profile leveling and cross-sections are surveying methods used to determine and document terrain elevations for infrastructure projects such as highways, railroads, canals, and pipelines. These methods provide data for earthwork planning and alignment of proposed routes. Profile leveling involves measuring elevations along a fixed line to create a vertical terrain profile. A surveyor sets up a leveling instrument at the benchmark (BM) and records a backsight (BS) to determine the...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Assembly and phylogenetic analysis of the mitochondrial genome of endangered medicinal plant Huperzia crispata.

Functional & integrative genomics·2023

Same author

Genomic diversity and evolution analysis of severe fever with thrombocytopenia syndrome in East Asia from 2010 to 2022.

Frontiers in microbiology·2023

Same author

Advances and challenges in biotechnological production of chondroitin sulfate and its oligosaccharides.

International journal of biological macromolecules·2023

Same author

lncRNA ARAP1-AS1 enhances proliferation and impairs apoptosis of lymphoma cells by sponging miR-6867-5p.

Cancer biomarkers : section A of Disease markers·2023

Same author

Pharmacological effects and mechanism of Kaihoujian Throat Spray (children's type) in the treatment of pediatric acute pharyngitis and tonsillitis.

Heliyon·2023

Same author

Computational Quantification of Cancer Immunoediting.

Cancer immunology research·2023

Search research articles

Related Experiment Video

Updated: Feb 6, 2026

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

TIP: A Web Server for Resolving Tumor Immunophenotype Profiling.

Liwen Xu¹, Chunyu Deng¹, Bo Pang¹

¹College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang, China.

Cancer Research

|August 30, 2018

Summary

This summary is machine-generated.

A new web tool, TIP, helps researchers evaluate tumor immunophenotype and anticancer immunity. This resource aids in understanding cancer immunity mechanisms and developing effective cancer immunotherapy biomarkers.

More Related Videos

Resolving Affinity Purified Protein Complexes by Blue Native PAGE and Protein Correlation Profiling

Resolving Affinity Purified Protein Complexes by Blue Native PAGE and Protein Correlation Profiling

Published on: April 1, 2017

Immunophenotyping of Orthotopic Homograft Syngeneic of Murine Primary KPC Pancreatic Ductal Adenocarcinoma by Flow Cytometry

Immunophenotyping of Orthotopic Homograft Syngeneic of Murine Primary KPC Pancreatic Ductal Adenocarcinoma by Flow Cytometry

Published on: October 9, 2018

Related Experiment Videos

Last Updated: Feb 6, 2026

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

Resolving Affinity Purified Protein Complexes by Blue Native PAGE and Protein Correlation Profiling

Resolving Affinity Purified Protein Complexes by Blue Native PAGE and Protein Correlation Profiling

Published on: April 1, 2017

Immunophenotyping of Orthotopic Homograft Syngeneic of Murine Primary KPC Pancreatic Ductal Adenocarcinoma by Flow Cytometry

Immunophenotyping of Orthotopic Homograft Syngeneic of Murine Primary KPC Pancreatic Ductal Adenocarcinoma by Flow Cytometry

Published on: October 9, 2018

Area of Science:

Oncology
Immunology
Bioinformatics

Background:

Systematic tracking of tumor immunophenotype is crucial for understanding cancer immunity.
Current research faces limitations due to a lack of comprehensive immune activity resources and user-friendly evaluation tools.
Evaluating immune activity within the cancer-immunity cycle is essential for advancing cancer immunotherapy.

Purpose of the Study:

To develop a user-friendly, one-stop web tool for comprehensive tumor immunophenotype analysis.
To enable convenient evaluation of anticancer immune activity and tumor-infiltrating immune cells.
To provide a platform for analyzing immune activity across the seven-step cancer-immunity cycle.

Main Methods:

Development of the Tumor Immunophenotype (TIP) web tool.
Implementation of rapid analysis and intuitive visualization of immune activity.
Pre-calculation of pan-cancer immunophenotypes for 11,373 The Cancer Genome Atlas (TCGA) samples across 33 human cancers.

Main Results:

TIP offers a user-friendly interface for biologists, clinicians, and researchers.
The tool facilitates rapid analysis and intuitive visualization of anticancer immunity.
Pre-calculated pan-cancer data allows for efficient comparison of tumor immunophenotypes.

Conclusions:

TIP serves as a valuable resource for evaluating anticancer immune activity using gene expression data.
The platform is expected to support numerous cancer immunity studies and biomarker development.
TIP is freely accessible, promoting broader application in cancer research and immunotherapy development.