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Long Non-Coding RNAs in Obesity-Induced Cancer
Mabel Yin-Chun Yau1, Lu Xu2, Chien-Ling Huang3
1School of Medical and Health Sciences, Tung Wah College, Hong Kong, China. mabelyau@twc.edu.hk.
Non-Coding RNA
|August 30, 2018
Summary
Long non-coding RNAs (lncRNAs) may play a role in obesity-induced cancers. Further research into lncRNAs could lead to new treatments for obesity-related cancers.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Obesity is a significant risk factor for various cancers, with several proposed mechanisms.
- The specific role of long non-coding RNAs (lncRNAs) in obesity-driven carcinogenesis remains largely unexplored.
Purpose of the Study:
- To review established mechanisms linking obesity to cancer.
- To summarize current evidence on cancer-associated lncRNAs in obese individuals.
- To propose the potential involvement of lncRNAs in obesity-induced cancers.
Main Methods:
- Literature review of obesity-cancer mechanisms.
- Synthesis of recent findings on lncRNA expression in obesity.
- Hypothetical framework for lncRNA contribution to cancer development.
Main Results:
- Established hypotheses for obesity-cancer links were discussed.
- Evidence for altered expression of known cancer-associated lncRNAs in obese subjects was summarized.
- A potential role for lncRNAs in mediating obesity's carcinogenic effects was proposed.
Conclusions:
- lncRNAs represent a potential, understudied area in obesity-induced cancers.
- Further investigation into lncRNA regulatory roles is crucial.
- Understanding lncRNAs may pave the way for novel therapeutic strategies against obesity-related cancers.
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