Related Experiment Video
Updated: Feb 6, 2026

Murine Orchiectomy and Ovariectomy to Reduce Sex Hormone Production
Published on: November 17, 2023
Sex Differences and the Influence of Sex Hormones on Cognition through Adulthood and the Aging Process
Caroline Gurvich1, Kate Hoy2, Natalie Thomas3
1Monash Alfred Psychiatry Research Centre, Central Clinical School, Monash University and The Alfred Hospital, Melbourne, VIC 3004, Australia. caroline.gurvich@monash.edu.
Abstract:
Hormones of the hypothalamic-pituitary-gonadal (HPG) axis that regulate reproductive function have multiple effects on the development, maintenance and function of the brain. Sex differences in cognitive functioning have been reported in both health and disease, which may be partly attributed to sex hormones. The aim of the current paper was to provide a theoretical review of how sex hormones influence cognitive functioning across the lifespan as well as provide an overview of the literature on sex differences and the role of sex hormones in cognitive decline, specifically in relation to Alzheimer's disease (AD). A summary of current hormone and sex-based interventions for enhancing cognitive functioning and/or reducing the risk of Alzheimer's disease is also provided.
Related Concept Videos
Sex-linked Disorders
Cognitive Development During Adulthood
Primary Motives: Sleep, Sex, and Pain Avoidance
Sleep is a fundamental physiological drive that fosters a state of restfulness crucial for several bodily functions. It facilitates body restoration, the process by which the body repairs, rejuvenates, and maintains itself during sleep, including memory...
Theory of Romantic Attachment in Adulthood
The Influence of Affect on Cognition
The Influence of Cognition on Affect

