Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sleepwalking and Sleep Talking01:17

Sleepwalking and Sleep Talking

1.0K
Somnambulism, commonly known as sleepwalking, involves individuals engaging in activities ranging from simple walking to more complex behaviors such as driving. Sleepwalking typically occurs during the slow-wave sleep stages 3 and 4 early in the night when the person is not dreaming, contradicting the myth that sleepwalkers are acting out their dreams.
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
1.0K
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

659
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
659
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.4K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.4K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

886
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
886
Uncertainty in Measurement: Accuracy and Precision03:37

Uncertainty in Measurement: Accuracy and Precision

102.4K
Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value. 
102.4K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

1.9K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effectiveness and probability of full disease control with canakinumab in familial Mediterranean fever: real-world data from the AIDA Network.

Rheumatology (Oxford, England)·2026
Same author

Long-term remission and monocyclic course in Still's disease patients starting canakinumab early: data from the international AIDA network registry.

Seminars in arthritis and rheumatism·2026
Same author

Risk of intestinal involvement in mucocutaneous-onset Behçet's disease: data from the AIDA network registry.

Frontiers in immunology·2026
Same author

Determinants of Non-infectious Scleritis Complications and Their Impact on Visual Outcome: Results from the International AIDA Network Scleritis Registry.

Ophthalmology and therapy·2026
Same author

Multicentre cohort study on the course of paediatric familial Mediterranean fever in the aftermath of the 2023 earthquake.

BMJ paediatrics open·2026
Same author

Evaluation of disease severity and treatment responses in patients with enthesitis-related arthritis.

Seminars in arthritis and rheumatism·2026

Related Experiment Video

Updated: Feb 6, 2026

Culture of Bladder Cancer Organoids as Precision Medicine Tools
08:39

Culture of Bladder Cancer Organoids as Precision Medicine Tools

Published on: December 28, 2021

5.5K

Vasculitis Pathogenesis: Can We Talk About Precision Medicine?

Seza Ozen1, Ezgi Deniz Batu2

  • 1Division of Rheumatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Frontiers in Immunology
|August 30, 2018
PubMed
Summary

Precision medicine tailors healthcare to individual variability. Existing data from genetic studies and biomarkers offer insights into primary systemic vasculitides (PSV), paving the way for targeted therapies.

Keywords:
biomarkergenome-wide association studiesmonogenic vasculitisprecision medicinesystemic vasculitis

More Related Videos

Accuracy in Dental Medicine, A New Way to Measure Trueness and Precision
07:57

Accuracy in Dental Medicine, A New Way to Measure Trueness and Precision

Published on: April 29, 2014

14.0K
Primary Human Nasal Epithelial Cells: Biobanking in the Context of Precision Medicine
08:35

Primary Human Nasal Epithelial Cells: Biobanking in the Context of Precision Medicine

Published on: April 22, 2022

3.5K

Related Experiment Videos

Last Updated: Feb 6, 2026

Culture of Bladder Cancer Organoids as Precision Medicine Tools
08:39

Culture of Bladder Cancer Organoids as Precision Medicine Tools

Published on: December 28, 2021

5.5K
Accuracy in Dental Medicine, A New Way to Measure Trueness and Precision
07:57

Accuracy in Dental Medicine, A New Way to Measure Trueness and Precision

Published on: April 29, 2014

14.0K
Primary Human Nasal Epithelial Cells: Biobanking in the Context of Precision Medicine
08:35

Primary Human Nasal Epithelial Cells: Biobanking in the Context of Precision Medicine

Published on: April 22, 2022

3.5K

Area of Science:

  • Rheumatology
  • Genetics
  • Immunology

Background:

  • Precision medicine aims to personalize healthcare based on individual variability.
  • Primary systemic vasculitides (PSV) are a group of rare autoimmune diseases.
  • Current understanding of PSV pathogenesis and individual patient profiles is evolving.

Purpose of the Study:

  • To evaluate the potential of existing data to guide precision medicine approaches in PSV.
  • To explore insights from genetic studies, monogenic mimics, and biomarker research in PSV.
  • To identify opportunities for more targeted therapies and improved patient management in PSV.

Main Methods:

  • Review of genome-wide association studies (GWAS) data relevant to PSV.
  • Analysis of findings from monogenic vasculitis studies, including phenotype mimicry.
  • Examination of biomarker studies in specific PSV, such as IgA vasculitis, Kawasaki disease, and AAV.

Main Results:

  • GWAS data offer insights into the underlying pathogenesis of PSV.
  • Monogenic vasculitides, caused by single gene alterations, can mimic other PSV phenotypes.
  • Biomarker studies are revealing new therapeutic targets and enabling structured patient follow-up.

Conclusions:

  • Existing genetic and biomarker data provide a foundation for precision medicine in PSV.
  • Discovery of monogenic vasculitides has led to more specific therapeutic strategies.
  • Proteomics and metabolomics are crucial for further patient categorization and targeted therapy development in PSV.