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Cardiac Involvement by HIV-Associated DLBCL

Charles T Mupamombe1, Jude Noel2, Derek B Laskar3

  • 1Department of Internal Medicine, STAR Clinic, SUNY Downstate Medical Center, Brooklyn, NY, USA.

Case Reports in Medicine
|August 30, 2018
PubMed

Insights

Diffuse large B-cell lymphoma (DLBCL) is a common cancer in people with HIV. Cardiac involvement is rare but indicates aggressive disease, with tachycardia and dysphagia as potential symptoms.

Area of Science:

  • Oncology
  • Infectious Diseases
  • Cardiology

Background:

  • Non-Hodgkin's lymphoma (NHL) is an AIDS-defining cancer, with diffuse large B-cell lymphoma (DLBCL) being the most prevalent type.
  • While DLBCL prognosis has improved in the general population, it remains challenging in HIV-positive individuals.
  • Cardiac involvement in DLBCL is uncommon but signifies aggressive disease progression.

Observation:

  • This case report details a patient with HIV experiencing DLBCL with cardiac involvement.
  • The patient presented with tachycardia and dysphagia as the sole indicators of cardiac compromise.
  • This highlights the subtle clinical presentation of rare cardiac manifestations in HIV-associated DLBCL.

Findings:

  • Diffuse large B-cell lymphoma (DLBCL) can manifest with cardiac involvement in HIV-positive patients.
  • Tachycardia and dysphagia were the presenting symptoms, suggesting potential cardiac infiltration.
  • This case underscores the importance of considering cardiac involvement in HIV-DLBCL, even with atypical symptoms.

Implications:

  • Early recognition of cardiac involvement in HIV-DLBCL is crucial for timely intervention.
  • Tachycardia and dysphagia may serve as early warning signs for cardiac compromise in this patient population.
  • Further research is needed to understand the mechanisms and optimal management of cardiac DLBCL in HIV-infected individuals.

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