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Updated: Feb 6, 2026

Synthesis and Characterization of Functionalized Metal-organic Frameworks
Published on: September 5, 2014
Stimuli-responsive metal-organic frameworks gated by pillar[5]arene supramolecular switches
Li-Li Tan1, Haiwei Li2, Yu-Chen Qiu1
1State Key Laboratory of Supramolecular Structure and Materials , College of Chemistry , International Joint Research Laboratory of Nano-Micro Architecture Chemistry (NMAC) , Jilin University , 2699 Qianjin Street , Changchun 130012 , P. R. China . Email: ywyang@jlu.edu.cn ;
Abstract:
Spurred on by recent advances in materials chemistry and drug delivery, a new stimuli-responsive theranostic hybrid platform, based on mechanized monodisperse nano metal-organic frameworks (NMOFs) gated by carboxylatopillar[5]arene (CP5) switches with bio-friendly pH-triggered cargo release capabilities, has been constructed for the first time. This nanoscale smart cargo delivery system showed pH- and/or competitive binding agent-triggered controlled cargo release with negligible premature release, large pore sizes for drug encapsulation, low cytotoxicity, good biodegradability and biocompatibility, and potential application in cell imaging, which offers a new tool in targeted drug delivery and the controlled release of therapeutic agents.
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