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Updated: Feb 6, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
A supramolecularly tunable chiral diphosphine ligand: application to Rh and Ir-catalyzed enantioselective
Xi-Chang Zhang1,2, Yi-Hu Hu1, Chuan-Fu Chen1
1College of Material, Chemistry and Chemical Engineering , Hangzhou Normal University , Hangzhou , China . Email: jingwubc@hznu.edu.cn ;
Abstract:
A supramolecularly tunable chiral bisphosphine ligand bearing two pyridyl-containing crown ethers, (-) or (+)-Xyl-P16C6-Phos, was fabricated and utilized in the Rh-catalyzed asymmetric hydrogenation of α-dehydroamino acid esters and Ir-catalyzed asymmetric hydrogenation of quinolines in high yields with excellent enantioselectivities (90-99% ee). Up to a 22% enhancement in enantioselectivity was achieved by the addition of certain amounts of alkali ions (Li+, Na+ or K+), which could be selectively recognized and effectively complexed by the crown ethers on the chiral Xyl-P16C6-Phos.
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