Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antibody-specific immunoregulation.

S K Pierce, N R Klinman

    The Journal of Experimental Medicine
    |August 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    The immune system can regulate antibody synthesis by recognizing self-idiotypes. This study shows a specific mechanism limits primary B-cell responses to an antigen, not secondary ones.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Maladaptive health factors as potential mediators for the association between posttraumatic stress disorder and cardiovascular disease: A sex-stratified analysis in the U.S. adult population.

    Journal of psychiatric research·2024
    Same author

    The Digestive Diverticula in the Carnivorous Nudibranch, <i>Melibe leonina</i>, Do Not Contain Photosynthetic Symbionts.

    Integrative organismal biology (Oxford, England)·2021
    Same author

    On the Giant Octopus (Octopus giganteus) and the Bermuda Blob: Homage to A. E. Verrill.

    The Biological bulletin·2017
    Same author

    Annual Viral Expression in a Sea Slug Population: Life Cycle Control and Symbiotic Chloroplast Maintenance.

    The Biological bulletin·2017
    Same author

    Is tolerance the result of engaging surface Ig of B cells in cycle?

    Immunology today·2014
    Same author

    B-cell development.

    Immunology today·2014

    Area of Science:

    • Immunology
    • B-cell biology
    • Humoral immunity

    Background:

    • The immune system can recognize self-antibody idiotypes.
    • Self-idiotypic recognition may regulate B-cell responses.

    Purpose of the Study:

    • Determine if animals develop specific regulation of antibody synthesis after primary immunization.
    • Investigate the role of self-idiotypic recognition in controlling B-cell responses.

    Main Methods:

    • Splenic fragment culture system used to compare B-cell responses.
    • Immunization with hemocyanin (Hy) alone or dinitrophenyl (DNP)-Hy plus Hy.
    • Assessed B-cell stimulation in irradiated recipients.

    Main Results:

    • A specific decrease (25-30%) in DNP-specific B-cell response observed in recipients immunized with both Hy and DNP-Hy.

    Related Experiment Videos

  • Responses to other haptens and secondary DNP-specific B-cell responses remained unaffected.
  • Control experiments confirmed the specificity of the observed regulatory mechanism.

    • Conclusions:

    • A T-dependent antigen induces an antibody-specific regulatory mechanism during primary immune response.
    • This mechanism specifically limits primary hapten-specific B-cell stimulation but not secondary responses.
    • Findings have implications for understanding B-cell response control and memory generation.