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Updated: Aug 5, 2026

Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example
Published on: November 18, 2015
Reaction discovery using acetylene gas as the chemical feedstock accelerated by the "stop-flow" micro-tubing reactor
Fei Xue1, Hongping Deng1, Chengwen Xue1
1Department of Chemistry , National University of Singapore , 3 Science Drive 3 , Republic of Singapore 117543 .
Abstract:
Acetylene gas has been applied as a feedstock under transition-metal catalysis and photo-redox conditions to produce important chemicals including terminal alkynes, fulvenes, and fluorinated styrene compounds. The reaction discovery process was accelerated through the use of "stop-flow" micro-tubing reactors. This reactor prototype was developed by joining elements from both continuous micro-flow and conventional batch reactors, which was convenient and effective for gas/liquid reaction screening. Notably, the developed transformations were either inefficient or unsuccessful in conventional batch reactors. Its success relies on the unique advantages provided by this "stop-flow" micro-tubing reactor system.
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