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Spontaneous Resolution of Symptomatic Hepatic Sarcoidosis
Viva Nguyen1, Henry Ngo, Henry N Ngo2,3
1Mercer University School of Medicine, Columbus, GA, USA.
Case Reports in Gastrointestinal Medicine
|August 30, 2018
Summary
Sarcoidosis, an inflammatory disease, can present as isolated liver granulomas. This case shows granulomatous hepatitis resolving spontaneously without treatment, highlighting a rare presentation of sarcoidosis.
Area of Science:
- Hepatology
- Immunology
- Internal Medicine
Background:
- Sarcoidosis is a systemic inflammatory disease of unknown cause.
- It typically involves noncaseating granulomas in various organs.
- Isolated extrapulmonary sarcoidosis, particularly affecting the liver, is uncommon.
Observation:
- A 60-year-old woman presented with persistently high alkaline phosphatase levels.
- A liver biopsy revealed granulomatous hepatitis, indicating potential sarcoidosis.
- No specific medical intervention was administered for the liver condition.
Findings:
- The patient's elevated alkaline phosphatase levels normalized spontaneously over three years.
- This suggests a self-limiting course for the granulomatous hepatitis in this case.
- The presentation underscores the possibility of isolated hepatic sarcoidosis.
Implications:
- This case expands the understanding of sarcoidosis presentations.
- It suggests that observation may be a viable management strategy for select cases of isolated hepatic granulomas.
- Further research into the natural history of hepatic sarcoidosis is warranted.
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