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Antibacterial Activity of Polyoxometalates Against Moraxella catarrhalis

Nadiia I Gumerova1, Emir Al-Sayed1, Lukáš Krivosudský1

  • 1Universität Wien, Fakultät für Chemie, Institut für Biophysikalische Chemie, Wien, Austria.

Frontiers in Chemistry
|August 30, 2018
PubMed

Insights

The Preyssler type polyoxotungstate [NaP5W30O110]14- showed the highest antibacterial activity against Moraxella catarrhalis. Several polyoxometalates (POMs) demonstrated selective activity, with some exhibiting bacteriostatic effects.

Area of Science:

  • Inorganic Chemistry
  • Materials Science
  • Antimicrobial Research

Background:

  • Polyoxometalates (POMs) are a diverse class of metal-oxygen cluster anions with unique structural and electronic properties.
  • Moraxella catarrhalis is a significant human pathogen, particularly implicated in respiratory tract infections and otitis media.

Purpose of the Study:

  • To investigate the antibacterial activity of various polyoxometalates (POMs) against Moraxella catarrhalis.
  • To identify the most potent POMs and understand the structure-activity relationships.

Main Methods:

  • Determination of minimum inhibitory concentrations (MICs) for 29 different POMs against M. catarrhalis.
  • MIC determination for selected active POMs against S. aureus, E. faecalis, and E. coli.
  • Bacteriostatic effect assessment using killing kinetics studies.

Main Results:

  • The Preyssler type polyoxotungstate [NaP5W30O110]14- exhibited the highest activity against M. catarrhalis (MIC = 1 microg/ml).
  • Dawson type POMs showed selective activity against M. catarrhalis (MIC range of 2-8 microg/ml).
  • [NaP5W30O110]14- was the most potent overall, with MICs of 16 microg/ml against S. aureus and 8 microg/ml against E. faecalis.

Conclusions:

  • POM activity against M. catarrhalis is influenced by composition, shape, and size.
  • For medium-sized Preyssler type polyoxotungstates, antibacterial activity correlates with total net charge.
  • Selected POMs, including [NaP5W30O110]14-, [P2W18O62]6-, and [H3P2W15V3O62]6-, display bacteriostatic effects against M. catarrhalis.
Keywords:
Dawson archetypeGram-negative pathogenPreyssler archetypebioactive polyoxometalatesmetal-oxo clustersminimum inhibitory concentrationtime-killing analysis

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