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Serum vitamin D level may be a novel potential risk factor for premature ejaculation: a comparative study

Alaa Mohamed Abd El Aal1, Sameh Fayek GamalEl Din1, Laila Ahmed Rashed2

  • 1Andrology & STDs Department, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt.

International Urology and Nephrology
|August 30, 2018
PubMed

Insights

Low vitamin D levels are linked to lifelong premature ejaculation (LPE). This study found significantly lower 25(OH)D in LPE patients, correlating with ejaculation latency and diagnostic tool scores.

Area of Science:

  • Urology
  • Endocrinology
  • Nutritional Science

Background:

  • Premature ejaculation (PE) is a common male sexual dysfunction.
  • The role of vitamin D in sexual health, particularly PE, requires further investigation.

Purpose of the Study:

  • To compare serum 25-hydroxyvitamin D [25(OH)D] levels between men with lifelong premature ejaculation (LPE) and healthy controls.
  • To investigate the correlation between vitamin D levels and parameters of ejaculatory function.

Main Methods:

  • A case-control study involving 40 men with LPE and 40 healthy controls.
  • Exclusion criteria included hormonal disorders, obesity, chronic diseases, and relevant medications.
  • Premature ejaculation diagnostic tool (PEDT) and intra-vaginal ejaculation latency time (IELT) were used for assessment. Serum 25(OH)D was measured via venous blood analysis.

Main Results:

  • 20% of participants exhibited vitamin D insufficiency/deficiency, all within the LPE group.
  • Serum 25(OH)D levels were significantly lower in LPE patients (35.75 ng/ml) compared to controls (58.92 ng/ml) (p < 0.001).
  • 25(OH)D showed significant negative correlations with IELT (r²=0.349) and PEDT scores (r²=0.425). A cut-off of 50.65 ng/ml for 25(OH)D predicted LPE with 85% sensitivity and specificity.

Conclusions:

  • Vitamin D deficiency is significantly associated with lifelong premature ejaculation.
  • Lower vitamin D levels correlate with reduced ejaculation latency and higher PE diagnostic scores.
  • Vitamin D status is a potential modifiable factor in managing LPE.
Abstract

Keywords:
Lifelong premature ejaculationSerotoninSerum vitamin DTryptophan hydroxylaseVitamin D deficiency

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