Serum vitamin D level may be a novel potential risk factor for premature ejaculation: a comparative study

Area of Science:

• Urology
• Endocrinology
• Nutritional Science

Background:

• Premature ejaculation (PE) is a common male sexual dysfunction.
• The role of vitamin D in sexual health, particularly PE, requires further investigation.

Purpose of the Study:

• To compare serum 25-hydroxyvitamin D [25(OH)D] levels between men with lifelong premature ejaculation (LPE) and healthy controls.
• To investigate the correlation between vitamin D levels and parameters of ejaculatory function.

Main Methods:

• A case-control study involving 40 men with LPE and 40 healthy controls.
• Exclusion criteria included hormonal disorders, obesity, chronic diseases, and relevant medications.
• Premature ejaculation diagnostic tool (PEDT) and intra-vaginal ejaculation latency time (IELT) were used for assessment. Serum 25(OH)D was measured via venous blood analysis.

Main Results:

• 20% of participants exhibited vitamin D insufficiency/deficiency, all within the LPE group.
• Serum 25(OH)D levels were significantly lower in LPE patients (35.75 ng/ml) compared to controls (58.92 ng/ml) (p < 0.001).
• 25(OH)D showed significant negative correlations with IELT (r²=0.349) and PEDT scores (r²=0.425). A cut-off of 50.65 ng/ml for 25(OH)D predicted LPE with 85% sensitivity and specificity.

Conclusions:

• Vitamin D deficiency is significantly associated with lifelong premature ejaculation.
• Lower vitamin D levels correlate with reduced ejaculation latency and higher PE diagnostic scores.
• Vitamin D status is a potential modifiable factor in managing LPE.