Related Experiment Video

Updated: Feb 6, 2026

Development and Validation of Chromium Getters for Solid Oxide Fuel Cell Power Systems
12:30

Development and Validation of Chromium Getters for Solid Oxide Fuel Cell Power Systems

Published on: May 26, 2019

7.8K

Clinical Validation of KIT Inhibition in Advanced Systemic Mastocytosis

John H Baird1, Jason Gotlib2

  • 1Division of Hematology, Stanford Cancer Institute / Stanford University School of Medicine, 875 Blake Wilbur Drive, Room 2324, Stanford, CA, 94305-5821, USA.

Current Hematologic Malignancy Reports
|August 30, 2018
PubMed
Abstract

Insights

Recent advances in treating advanced systemic mastocytosis (advSM) focus on KIT inhibitors. New targeted therapies show promise for managing this rare cancer, though further research is needed.

Area of Science:

  • Oncology
  • Hematology
  • Molecular Biology

Background:

  • Advanced systemic mastocytosis (advSM) is a rare, aggressive cancer.
  • Neoplastic mast cell accumulation drives advSM.
  • The KIT D816V mutation is a key driver in most advSM cases.

Purpose of the Study:

  • To review recent developments in treating advSM.
  • To discuss the role of KIT receptor tyrosine kinase inhibitors.

Main Methods:

  • Review of current literature on KIT inhibitors for advSM.
  • Analysis of clinical trial data for approved and investigational therapies.

Main Results:

  • Midostaurin, a KIT inhibitor, is approved for advSM, showing efficacy in reducing organ damage and symptoms.
  • Newer, selective KIT D816V inhibitors (avapritinib, DCC-2618) are in clinical trials.
  • KIT inhibitors confirm KIT's role in mast cell neoplasms.

Conclusions:

  • KIT inhibitors represent a significant advancement in advSM treatment.
  • Understanding genetic heterogeneity beyond KIT is crucial for optimizing response and managing relapse.
Keywords:
AvapritinibImatinibKIT D816VMidostaurinSystemic mastocytosis

More Related Videos

Author Spotlight: Advances in Nanoscale Infrared Spectroscopy to Explore Multiphase Polymeric Systems06:54

Author Spotlight: Advances in Nanoscale Infrared Spectroscopy to Explore Multiphase Polymeric Systems

Published on: June 23, 2023

1.4K
A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.5K

Related Concept Videos

Reliability and Validity01:29

Reliability and Validity

Reliability and validity are two important considerations that must be made with any type of data collection. Reliability refers to the ability to consistently produce a given result. In the context of psychological research, this would mean that any instruments or tools used to collect data do so in consistent, reproducible ways.
14.0K
Feedback Inhibition00:46

Feedback Inhibition

Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
57.2K
Data Validation01:15

Data Validation

Method validation is a crucial process in analytical chemistry designed to confirm that a given method consistently produces reliable and high-quality results. This process is essential when a method is applied to different sample matrices or when procedural modifications are made, ensuring that the results meet acceptable standards across various applications.
Key parameters for method validation include:
2.0K
Data Validation01:03

Data Validation

Data validation is an essential part of a comprehensive assessment. Validation is confirming or verifying and opening the door to gathering more assessment data as it clarifies vague or unclear data. The process of checking and verifying the collected information is called data validation. The primary purpose of data validation is to ensure data is as free from error, bias, and misinterpretation as possible.
Nursing assessment guides are generally based on holistic models rather than medical...
6.8K
Enzyme Inhibition01:30

Enzyme Inhibition

Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.
92.5K
Overview of Advanced Functional Groups02:22

Overview of Advanced Functional Groups


Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
30.1K