Characteristics of early sacubitril/valsartan patients and considerations for studies in electronic health record

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Joshua J Gagne1, Theodore Tsacogianis1, Sara Bruce Wirta2

  • 1Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02120, USA.

Journal of Comparative Effectiveness Research
|August 30, 2018
PubMed

Insights

Early users of sacubitril/valsartan for heart failure (HF) were younger and often had prior HF treatment. These patients resembled those with HF with reduced ejection fraction and used other HF medications.

Area of Science:

  • Cardiology
  • Pharmacology
  • Real-world evidence

Background:

  • Sacubitril/valsartan is a novel treatment for heart failure (HF).
  • Understanding early adoption patterns is crucial for optimizing HF management.

Purpose of the Study:

  • To characterize early users of sacubitril/valsartan in a large US electronic health records database.
  • To compare early sacubitril/valsartan users with other heart failure patient cohorts.

Main Methods:

  • Retrospective analysis of a US electronic health records database.
  • Identification of three heart failure cohorts: sacubitril/valsartan users, HF with reduced ejection fraction (HFrEF), and standard therapy (ACEi/ARB + beta-blocker).

Main Results:

  • Sacubitril/valsartan patients were younger compared to other HF cohorts.
  • The mean age of sacubitril/valsartan users increased over the initial 15 months of market availability.
  • Most sacubitril/valsartan initiators had prior heart failure treatment.

Conclusions:

  • Early sacubitril/valsartan users largely mirrored the characteristics of the HFrEF cohort.
  • Concurrent use of other heart failure medications was common among sacubitril/valsartan patients.
Abstract

Keywords:
cardiology/cardiovascularheart failureobservational researchoutcomes researchsacubitril/valsartanutilization

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