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Melatonin as Potential Targets for Delaying Ovarian Aging
Yanzhou Yang1, Hoi-Hung Cheung2, Cheng Zhang3
1Key Laboratory of Fertility Preservation and Maintenance, Ministry of Education, Key Laboratory of Reproduction and Genetics in Ningxia, Ningxia Medical University, Yinchuan, Ningxia, 75004, China.
Current Drug Targets
|August 30, 2018
Summary
Ovarian aging involves more than oxidative stress, including factors like autophagy and mitochondrial dysfunction. Melatonin shows promise in delaying ovarian aging by targeting these interconnected pathways.
Area of Science:
- Reproductive biology
- Gerontology
- Biochemistry
Background:
- Ovarian aging was previously attributed solely to oxidative stress.
- Emerging evidence links ovarian aging to endoplasmic reticulum stress, autophagy, mitochondrial dysfunction, and genetic factors.
- These factors interact with oxidative stress, necessitating a broader understanding of ovarian aging.
Purpose of the Study:
- To review the multifaceted mechanisms of ovarian aging.
- To explore the extensive role of melatonin in regulating ovarian aging.
- To propose melatonin as a potential therapeutic agent for ovarian aging.
Main Methods:
- Systematic review of current literature on ovarian aging mechanisms.
- Analysis of the pleiotropic effects of melatonin.
- Integration of research on oxidative stress, endoplasmic reticulum stress, autophagy, and other aging-related factors.
Main Results:
- Ovarian aging is a complex process influenced by multiple interacting factors beyond oxidative stress.
- Melatonin, a potent antioxidant, influences various pathways involved in ovarian aging.
- Melatonin's multifaceted regulatory actions suggest its potential in mitigating ovarian aging.
Conclusions:
- Ovarian aging involves a complex interplay of oxidative stress, endoplasmic reticulum stress, autophagy, and other cellular processes.
- Melatonin demonstrates significant potential as a therapeutic agent to delay ovarian aging due to its broad regulatory effects.
- This review provides novel insights into ovarian aging mechanisms and highlights melatonin as a promising treatment strategy.
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