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Related Concept Videos

Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
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Cognitive therapy, pioneered by Aaron T. Beck in the 1960s, is a structured approach to addressing psychological distress by focusing on the influence of thoughts on emotions and behaviors. All cognitive therapies involve the basic assumption that human beings have control over their feelings, and that how individuals feel about something depends on how they think about it. Unlike psychoanalytic methods that delve into unconscious processes or humanistic approaches emphasizing...
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Related Experiment Video

Updated: Feb 6, 2026

Culture of Embryonic Mouse Cochlear Explants and Gene Transfer by Electroporation
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Toward Cochlear Therapies.

Jing Wang1, Jean-Luc Puel1

  • 1INSERM UMR 1051, Institute for Neurosciences of Montpellier , Montpellier , France ; and University of Montpellier, Montpellier , France.

Physiological Reviews
|August 30, 2018
PubMed
Summary

Sensorineural hearing impairment, a common disorder, stems from cochlear cell degeneration. Emerging therapies offer hope for preventing and restoring hearing loss caused by various factors.

Area of Science:

  • Oto-rhino-laryngology
  • Neuroscience
  • Regenerative Medicine

Background:

  • Sensorineural hearing impairment is a prevalent sensory disorder linked to cochlear cell degeneration.
  • Causative factors include ototoxic drugs, noise exposure, aging, and genetic predispositions.
  • Current treatments lack the ability to regenerate or rescue damaged auditory cells.

Purpose of the Study:

  • To review the molecular mechanisms of cochlear damage and endogenous protection pathways.
  • To explore recent advancements in therapeutic strategies for hearing loss.
  • To discuss the potential clinical applications of novel hearing restoration research.

Main Methods:

  • Review of current literature on molecular pathways in cochlear damage.
  • Analysis of recent research in pharmacological, gene, and cell-based therapies.

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  • Evaluation of potential clinical translation of these therapeutic approaches.

    • Main Results:

    • Understanding of molecular pathways underlying cochlear sensorineural damage and survival signaling.
    • Identification of therapeutic targets for preventing and treating hearing loss.
    • Promising developments in genetic and cell-replacement therapies for hearing restoration.

    Conclusions:

    • Novel therapeutic targets offer hope for preventing and treating various forms of hearing loss.
    • Pharmacological, gene, and cell therapies show potential for hearing protection and restoration.
    • Further research is needed to translate these findings into clinical applications for deaf individuals.