Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Natural Selection?01:32

What is Natural Selection?

129.5K
Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
129.5K
Nature and Nurture01:10

Nature and Nurture

22.4K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
22.4K
Humoral Immune Responses01:36

Humoral Immune Responses

84.0K
Overview
84.0K
System of Memory01:23

System of Memory

7.4K
Memory is categorized into three major systems: sensory memory, short-term memory (STM), and long-term memory (LTM). These systems differ in their capacity and the duration for which they can hold information. Sensory memory captures raw sensory input from the environment, holding it for just a few seconds or less. For example, on hearing a brief, loud sound, like a car horn honking, the sound seems to linger in the mind for a moment even after it stops. This is an instance of sensory memory...
7.4K
Working Memory01:24

Working Memory

899
Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
899
Long-Term Memory01:18

Long-Term Memory

696
Long-term memory is a relatively permanent type of memory, capable of storing vast amounts of information over extended periods. Its storage capacity is generally considered unlimited.
Long-term memory can be categorized into two primary types: explicit and implicit memory. Explicit memory, also known as declarative memory, involves the conscious recollection of information that we deliberately try to remember, recall, and articulate. This type of memory encompasses specific facts, events, and...
696

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The impact of ovarian stimulation on the human endometrial microenvironment.

Human reproduction (Oxford, England)·2024
Same author

Maternal IL-33 critically regulates tissue remodeling and type 2 immune responses in the uterus during early pregnancy in mice.

Proceedings of the National Academy of Sciences of the United States of America·2022
Same author

Transcriptional and epigenetic regulation of memory NK cell responses.

Immunological reviews·2021
Same author

Endothelial Jagged1 Antagonizes Dll4/Notch Signaling in Decidual Angiogenesis during Early Mouse Pregnancy.

International journal of molecular sciences·2020
Same author

Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition.

Nature immunology·2020
Same author

Corrigendum: Transcriptional Regulation of Mouse Tissue-Resident Natural Killer Cell Development.

Frontiers in immunology·2020
Same journal

Correction to: IL-27 signaling negatively regulates FcɛRI-mediated mast cell activation and allergic response.

Journal of leukocyte biology·2026
Same journal

Autofluorescence enables detection and quantification of EETosis in human leukocyte cultures.

Journal of leukocyte biology·2026
Same journal

Cold Atmospheric Plasma as an Immunomodulator: Suppression of T-cell Hyperactivation and Graft-versus-Host Disease via Redox Regulation.

Journal of leukocyte biology·2026
Same journal

Distinct lymphocyte immune signatures to nivolumab and recombinant IL-7 ex vivo in patients with sepsis.

Journal of leukocyte biology·2026
Same journal

Eosinophil Essentials: Identification and Assessment of Activity.

Journal of leukocyte biology·2026
Same journal

Immune cell landscape reveals 5 immune-related subtypes and molecular characteristics with prognostic and therapeutic implications in pan-cancer.

Journal of leukocyte biology·2026
See all related articles

Related Experiment Video

Updated: Feb 6, 2026

A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro
10:36

A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro

Published on: January 9, 2018

7.6K

Memory responses by natural killer cells.

Aimee M Beaulieu1,2

  • 1Center for Immunity and Inflammation, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers-The State University of New Jersey, Newark, New Jersey, USA.

Journal of Leukocyte Biology
|August 30, 2018
PubMed
Summary
This summary is machine-generated.

Natural killer (NK) cells, crucial for immunity, can develop long-lived, antigen-specific memory. This review explores adaptive NK cell responses in infection and cancer.

Keywords:
ILCNKadaptivecytomegalovirushaptenmemory-like

More Related Videos

Analysis of Human Natural Killer Cell Metabolism
09:03

Analysis of Human Natural Killer Cell Metabolism

Published on: June 22, 2020

7.4K
Teasing Out the Interplay Between Natural Killer Cells and Nociceptor Neurons
09:40

Teasing Out the Interplay Between Natural Killer Cells and Nociceptor Neurons

Published on: June 30, 2022

2.7K

Related Experiment Videos

Last Updated: Feb 6, 2026

A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro
10:36

A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro

Published on: January 9, 2018

7.6K
Analysis of Human Natural Killer Cell Metabolism
09:03

Analysis of Human Natural Killer Cell Metabolism

Published on: June 22, 2020

7.4K
Teasing Out the Interplay Between Natural Killer Cells and Nociceptor Neurons
09:40

Teasing Out the Interplay Between Natural Killer Cells and Nociceptor Neurons

Published on: June 30, 2022

2.7K

Area of Science:

  • Immunology
  • Cellular Biology

Background:

  • Natural killer (NK) cells are key innate immune cells for defense against pathogens and cancer.
  • Emerging evidence suggests NK cells possess adaptive immune features, including long-lived, antigen-specific memory responses.
  • Anamnestic NK cell responses are observed in various settings, such as viral/bacterial infections and alloantigen responses.

Purpose of the Study:

  • To provide an overview of studies on adaptive NK cell responses.
  • To discuss the molecular, transcriptional, and epigenetic regulation of these memory-like NK cells.
  • To highlight the identification of memory-like NK cells in humans, particularly during human cytomegalovirus (HCMV) infection.

Main Methods:

  • Review of existing literature on NK cell memory.
  • Analysis of molecular, transcriptional, and epigenetic pathways.
  • Case studies focusing on specific infections (e.g., HCMV).

Main Results:

  • NK cells exhibit immunological memory, characterized by enhanced recall responses.
  • Memory-like NK cell populations are identified in both mice and humans.
  • These responses are antigen-specific and long-lived.

Conclusions:

  • NK cells demonstrate adaptive immune capabilities beyond their innate functions.
  • Understanding the regulation of adaptive NK cells is crucial for developing novel immunotherapies.
  • Further research into NK cell memory mechanisms can enhance treatments for infections and cancer.