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Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry
Published on: April 9, 2021
Remote Site-Specific Radical Alkynylation of Unactivated C-H Bonds
Lin Wang1, Yong Xia1, Klaus Bergander1
1Institute of Organic Chemistry , University of Münster , Corrensstrasse 40 , 48149 Münster , Germany.
Abstract:
A method for remote radical C-H alkynylation at unactivated sites is reported. C-H functionalization proceeds via 1,5-hydrogen atom transfer (HAT) to amidyl radicals that are generated via an addition/fragmentation reaction. The readily installed N-allylsulfonyl moiety is used as a precursor of the N-centered radical. Unactivated secondary and tertiary as well as selected primary C-H bonds can be functionalized by this method.
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