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Updated: Feb 6, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
Sickle Cell Leg Ulcers: A Case Study
1Courtney Kendall, BSN, RN, is a graduate Nurse Practitioner student at Virginia Commonwealth University, completing her final clinical practicum in the Plastic and Reconstructive Surgery department at VCU Health, Richmond, VA. She works in the medical-intensive care unit at Virginia Commonwealth University, Richmond, VA.
Abstract:
Sickle cell disease is an autosomal recessive genetic disorder that affects the shape and function of red blood cells, causing a myriad of systemic complications. Rigid and deformed red blood cells can become trapped in the microvascular circulation, causing tissue ischemia and severe pain. Skin ulcerations of the lower extremities present a unique challenge for patients suffering from this condition. This case study discusses the pathophysiology of these ulcers, treatment options, and a patient case.
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