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Updated: Feb 6, 2026

Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing
Published on: December 13, 2024
Effects of Hydrogel With Enriched Sodium Alginate in Wounds of Diabetic Patients
Murilo Antonio Gustinelli Barbosa1, André Oliveira Paggiaro, Viviane Fernandes de Carvalho
1Murilo Antonio Gustinelli Barbosa, MN, is Nurse, Guarulhos University, São Paulo, Brazil. André Oliveira Paggiaro, PhD, is Plastic Surgeon, Guarulhos University, São Paulo, Brazil. Viviane Fernandes de Carvalho, PhD, is Nurse, Guarulhos University, São Paulo, Brazil. César Isaac, PhD, is Plastic Surgeon, São Paulo University, São Paulo, Brazil. Rolf Gemperli, PhD, is Plastic Surgeon, São Paulo University, São Paulo, Brazil.
Abstract:
Objective of this study was to evaluate the efficacy of the autolytic debridement promoted by hydrogel with sodium alginate enriched with fatty acids and vitamins A and E in the healing of foot wounds in diabetic patients. A clinical study was conducted at an outpatient clinic of medical specialties. The sample comprised 8 patients supervised for a 3-month period, from April to July 2017, by means of a clinical history, photographic record, planimetry, and classification of the wound severity by the Pressure Ulcer Scale for Healing (PUSH) system. Of the 8 patients supervised, 1 dropped out and 7 were followed up for 12 weeks. Only 2 had complete wound healing, but all presented a reduction of the lesion area of approximately 22.2% and PUSH score of 9.8 to 6.6. This study found that hydrogel showed good results for the treatment of diabetic feet, reducing the area and overall PUSH score of the wounds.
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