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Cognitive function in patients with coronary artery disease: A literature review

J Burkauskas1, P Lang2, A Bunevičius3

  • 11 Behavioral Medicine Institute, Lithuanian University of Health Sciences, Vydūno Str. 4/J. Šliūpo Str. 7, LT-00135, Palanga, Lithuania.

The Journal of International Medical Research
|August 31, 2018
PubMed

Insights

Cognitive function in coronary artery disease (CAD) patients is influenced by factors like surgery and genetics. Further research is needed to clarify the impact of left ventricular ejection fraction, medications, and biomarkers on cognitive decline.

Area of Science:

  • Cardiology
  • Neurology
  • Medical Research

Background:

  • Cognitive impairment is a known complication of cerebrovascular disease.
  • Factors influencing cognitive function decline in coronary artery disease (CAD) patients are less understood.

Purpose of the Study:

  • To review recent studies on factors associated with cognitive function in CAD patients.
  • To identify key determinants of cognitive decline in individuals with coronary artery disease.

Main Methods:

  • Systematic literature search of MEDLINE/PubMed for studies published between 2010 and 2016.
  • Inclusion criteria focused on studies addressing factors affecting cognitive function in the CAD population.
  • Review of 32 selected publications from an initial pool of 227.

Main Results:

  • Five factors tentatively linked to cognitive function in CAD patients were identified: coronary artery bypass grafting (CABG) surgery, apolipoprotein E4 (APOE4) genotype, left ventricular ejection fraction (LVEF), medication use, and hormones/biomarkers.
  • Improved CABG techniques may reduce postoperative cognitive decline.
  • The influence of APOE4 genotype, LVEF, and cardiovascular medications remains under investigation.

Conclusions:

  • While CABG advancements show promise for cognitive health, the roles of APOE4, LVEF, and medications require further clarification.
  • Associations between thyroid hormones, biomarkers, and cognitive function in CAD patients are noted but require more research.
  • Longitudinal and cross-sectional studies are recommended to elucidate these relationships and explore other causes of cognitive decline in CAD.

Keywords:
APOE4 genotypeCognitive functionbiomarkerscoronary artery bypass graftingcoronary artery diseaseleft ventricular ejection fractionmedication use

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