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Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
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Downregulated microRNAs in the colorectal cancer: diagnostic and therapeutic perspectives

Rosa Hernández1, Ester Sánchez-Jiménez2, Consolación Melguizo1

  • 1Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, Granada 18100; Biosanitary Institute of Granada (ibs. GRANADA), SAS-Universidad de Granada, Granada 18100; Department of Human Anatomy and Embryology, School of Medicine, University of Granada, Granada 18100, Spain.

BMB Reports
|August 31, 2018
PubMed

Insights

MicroRNAs (miRNAs) show abnormal levels in colorectal cancer (CRC), impacting its development and treatment. Downregulated miRNAs are promising for CRC diagnosis and targeted therapies.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Colorectal cancer (CRC) lacks specific diagnostic and therapeutic biomarkers.
  • MicroRNAs (miRNAs) are small RNAs regulating gene expression and are implicated in CRC initiation, progression, and drug resistance.

Purpose of the Study:

  • To review the potential applications of miRNAs in colorectal cancer diagnosis, prognosis, and treatment.
  • To highlight the significance of downregulated miRNAs in CRC management.

Main Methods:

  • Literature review of studies on miRNA roles in colorectal cancer.
  • Analysis of miRNA expression patterns and their correlation with CRC characteristics.

Main Results:

  • Aberrant miRNA levels are associated with CRC initiation, progression, and drug resistance.
  • Specific miRNA expression patterns correlate with CRC diagnosis, prognosis, and therapeutic response.
  • Downregulated miRNAs show potential as diagnostic markers and therapeutic targets for CRC.

Conclusions:

  • MicroRNAs are crucial regulators of cellular mechanisms in colorectal cancer.
  • Downregulated miRNAs represent valuable candidates for CRC diagnosis and targeted tumor-suppressing therapies.

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