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Delineating Pro-Angiogenic Myeloid Cells in Cancer Therapy.

Benjamin W Johnson1, Bhagelu R Achyut2, Sadanand Fulzele3

  • 1Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. bejohnson1@augusta.edu.

International Journal of Molecular Sciences
|August 31, 2018
PubMed
Summary

Myeloid cells play a key role in cancer development and resistance to therapy. Understanding the specific subset of angiogenic myeloid cells is crucial for developing targeted immune therapies against tumors.

Keywords:
MDSCangiogenicantiangiogenicchemotherapyimmunotherapymyeloidradiotherapytumor

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Area of Science:

  • Oncology
  • Immunology
  • Cancer Research

Background:

  • Myeloid cells are increasingly recognized for their critical roles in cancer progression and therapy resistance.
  • Tumor-associated myeloid cells are a focus for novel immune-based cancer therapies.
  • Myeloid cell populations within tumors are highly heterogeneous.

Purpose of the Study:

  • To review and consolidate current literature on angiogenic myeloid cells.
  • To elucidate the function of angiogenic myeloid cells in solid tumors.
  • To highlight the role of these cells in therapeutic refractoriness.

Main Methods:

  • Literature review of preclinical and clinical studies.
  • Analysis of data on myeloid cell heterogeneity and function.
  • Synthesis of information on angiogenesis and myeloid cell interactions in cancer.

Main Results:

  • Identified a subset of myeloid cells with significant angiogenic properties within solid tumors.
  • Demonstrated the contribution of these angiogenic myeloid cells to tumor growth and metastasis.
  • Highlighted the association between angiogenic myeloid cells and resistance to various cancer therapies.

Conclusions:

  • Angiogenic myeloid cells represent a critical, yet underappreciated, component of the tumor microenvironment.
  • Specific targeting of these protumor myeloid cells offers a promising strategy for overcoming therapy resistance.
  • Further research is needed to delineate and therapeutically exploit angiogenic myeloid cell populations.