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Swinging heart caused by diffuse large B-cell lymphoma

Raúl A Montañez-Valverde1,2, Neal Ivan Olarte3, Gerardo Zablah3

  • 1Beth Israel Deaconess Medical Center/Harvard Medical School, Cardiovascular Division, Boston, MA, USA.

Oxford Medical Case Reports
|August 31, 2018
PubMed

Insights

Malignant pericardial effusion is rare in non-Hodgkin's lymphoma. This case highlights a young male with diffuse large B-cell lymphoma who experienced cardiac tamponade due to malignant pericardial effusion.

Area of Science:

  • Oncology
  • Cardiology
  • Pathology

Background:

  • Pericardial disease is a known complication of various cancers, often resulting from tumor spread or lymphatic obstruction.
  • Malignant pericardial effusion, while documented in solid tumors, is an infrequent occurrence in hematologic malignancies, particularly non-Hodgkin's lymphoma.

Observation:

  • A 31-year-old male diagnosed with diffuse large B-cell lymphoma presented with symptoms indicative of cardiac tamponade.
  • Diagnostic evaluation revealed a malignant pericardial effusion as the cause of the patient's cardiac compromise.

Findings:

  • The case underscores the uncommon presentation of malignant pericardial effusion in the context of diffuse large B-cell lymphoma.
  • The effusion was attributed to the direct involvement of the pericardium by the lymphoma or secondary effects of mediastinal lymphadenopathy.

Implications:

  • This case emphasizes the importance of considering malignant pericardial effusion in lymphoma patients presenting with cardiac symptoms.
  • Early diagnosis and management of malignant pericardial effusion are crucial for preventing life-threatening complications like cardiac tamponade in lymphoma patients.

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