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Updated: Feb 6, 2026
09:02
Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
22.5K
Chronic Lymphocytic Leukemia and Myelofibrosis
Fares Darawshy1, Arieh Ben-Yehuda1, Karine Atlan2
1Internal Medicine Division, Internal Medicine C Department, Hebrew University-Hadassah Medical Organization, Jerusalem, Israel.
Case Reports in Hematology
|August 31, 2018
Summary
This case report details an unusual instance of chronic lymphocytic leukemia (CLL) developing into primary myelofibrosis (PMF). The study highlights the rare association and discusses the role of JAK-2 V617F mutation in this dual malignancy.
Area of Science:
- Hematology
- Oncology
- Genetics
Background:
- Chronic lymphocytic leukemia (CLL) is rarely associated with myelofibrosis.
- The co-occurrence of CLL and primary myelofibrosis (PMF) is exceptionally uncommon, with limited case reports in existing literature.
Observation:
- An 86-year-old female with CLL developed splenomegaly and elevated LDH levels 27 months post-diagnosis.
- Bone marrow biopsy confirmed PMF, revealing a JAK-2 V617F mutation.
Findings:
- Patients with concurrent CLL and PMF are typically older.
- PMF developing after a CLL diagnosis is the most frequent clinical progression.
- JAK-2 V617F mutation is present in 48.7% of patients with this dual diagnosis.
Implications:
- This case underscores the unusual progression of CLL to PMF.
- Investigating the etiological and pathogenic links, including the JAK-2 V617F mutation, is crucial for understanding this rare dual malignancy.
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