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Molecular characterization and clinical epidemiology of HCV in District Dir (Lower), Pakistan

Sami Ullah1,2, Muhammad Akram Khan3, Shafiq Ur Rahman4

  • 11Department of Biotechnology, Shaheed Benazir Bhutto University, Dir Upper, Pakistan.

Virusdisease
|August 31, 2018
PubMed

Insights

Hepatitis C virus (HCV) infection is prevalent in Pakistan, with genotype 3 being common. Unsafe injections at local clinics significantly contribute to HCV transmission, particularly among males.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Hepatitis C virus (HCV) infection affects approximately 200 million people globally.
  • Geographic variations exist in hepatitis C prevalence and HCV genotypes/subtypes.

Purpose of the Study:

  • To determine the prevalence of Hepatitis C and its genotypes/subtypes in District Dir (Lower), Pakistan.
  • To identify epidemiological factors and transmission routes of HCV in the study population.

Main Methods:

  • Multiplex PCR was used for genotyping HCV from blood samples of positive patients.
  • A structured questionnaire collected patient information.
  • Statistical analysis was performed for epidemiological parameters.

Main Results:

  • Hepatitis C genotype 3 was found to be prevalent.
  • HCV infection was more frequent in males (P < 0.01).
  • Injections at local clinics emerged as a significant transmission route (P < 0.002).

Conclusions:

  • The study identified genotype 3 as the predominant HCV type in District Dir (Lower).
  • Unsafe injection practices in local clinics are a major driver of HCV transmission.
  • Findings underscore the need for targeted interventions and further research for effective HCV control strategies.

Keywords:
EpidemiologyGenotypingHCVLiver cancerPrevalence

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