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Interactions between anticancer active platinum complexes and non-coding RNAs/microRNAs

Bernhard Biersack1

  • 1Organic Chemistry Laboratory, University of Bayreuth, Universitätsstraße 30, 95447, Bayreuth, Germany.

Non-Coding RNA Research
|August 31, 2018
PubMed

Insights

MicroRNAs (miRNAs) significantly influence how cancer cells respond to platinum-based drugs like cisplatin. These small RNA molecules regulate both the effectiveness and resistance to platinum therapies in various cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Platinum(II) complexes, including cisplatin, carboplatin, and oxaliplatin, are mainstays in solid tumor treatment.
  • Cancer cell behavior and drug response are modulated by non-coding RNA, specifically microRNAs (miRNAs).

Purpose of the Study:

  • To review the intricate relationship between platinum-based chemotherapy and microRNAs.
  • To discuss how microRNAs impact platinum drug efficacy and resistance across different cancer types.

Main Methods:

  • Literature review of studies investigating platinum drugs and microRNAs.
  • Analysis of research on miRNA-mediated regulation of platinum sensitivity and resistance.

Main Results:

  • MicroRNAs play a dual role, capable of both enhancing platinum drug activity and mediating tumor resistance.
  • Specific miRNAs have been identified as key regulators in the response to platinum-based therapies.

Conclusions:

  • Understanding miRNA-platinum drug interactions is crucial for optimizing cancer treatment strategies.
  • Targeting miRNAs presents a potential avenue for overcoming resistance to platinum chemotherapy.
Keywords:
5-FU, 5-fluorouracilAnticancer drugsCBDCA, cyclobutane-1,1-dicarboxylateCarboplatinCisplatinDACH, 1,2-diaminocyclohexaneDDP, cisplatinEGCG, (−)-epigallocatechin-3-gallateEOX, epirubicin/oxaliplatin/xelodaFOLFOX, folinate/5-FU/oxaliplatinGC, gemcitabine/cisplatin, gastric cancerLNA, locked nucleic acidMVAC, methotrexate/vinblastine/adriamycin/cisplatinMicroRNAOxaliplatinPlatinum complexesXELOX, xeloda/oxaliplatindTTP, deoxythymidine triphosphate

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