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Related Concept Videos

siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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piRNA - Piwi-interacting RNAs02:57

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PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
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Deformation in a Circular Shaft01:10

Deformation in a Circular Shaft

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One of the distinctive characteristics of circular shafts is their ability to maintain their cross-sectional integrity under torsion. In other words, each cross-section continues to exist as a flat, unaltered entity, simply rotating like a solid, rigid slab. To understand the distribution of shearing stress within such a shaft, consider a cylindrical section inside this circular shaft. This section has a length of L and a radius of R, with one end fixed. The radius of the cylindrical section is...
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Related Experiment Video

Updated: Feb 6, 2026

Use of Alu Element Containing Minigenes to Analyze Circular RNAs
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Use of Alu Element Containing Minigenes to Analyze Circular RNAs

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Circular RNAs in the cardiovascular system.

Clarissa P C Gomes1, Antonio Salgado-Somoza1, Esther E Creemers2

  • 1Cardiovascular Research Unit, Luxembourg Institute of Health, Luxembourg, Luxembourg.

Non-Coding RNA Research
|August 31, 2018
PubMed
Summary

Circular RNAs (circRNAs) are key gene expression regulators in cardiovascular health and disease. This review explores their role, biogenesis, and potential as biomarkers, with AI aiding research.

Keywords:
Artificial intelligenceBiomarkerCRISPR, clustered regularly interspaced short palindromic repeatsCV, cardiovascularCardiovascular diseaseCardiovascular systemCircular RNAsDCM, dilated cardiomyopathyEMT, epithelial-mesenchymal transitionNon-coding RNAsRNA-seq, RNA sequencingRPAD, RNase R treatment followed by polyadenylation and poly(A)+ RNA depletionRT-qPCR, reverse transcription quantitative polymerase chain reactioncircRNAs, circular RNAslncRNAs, long non-coding RNAsmiRNAs, microRNAsncRNAs, non-coding RNAs

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Identification of Circular RNAs using RNA Sequencing
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Area of Science:

  • Molecular Biology
  • Genetics
  • Cardiovascular Science

Background:

  • Circular RNAs (circRNAs) are increasingly recognized as crucial regulators of gene expression.
  • They represent a novel class of non-coding RNAs with ubiquitous expression.
  • Emerging evidence highlights their involvement in cardiovascular physiology and pathology.

Purpose of the Study:

  • To provide a comprehensive overview of circRNAs in cardiovascular health and disease.
  • To summarize current knowledge on circRNA biogenesis, expression, regulation, and function in the cardiovascular system.
  • To discuss technical aspects of circRNA research, including the role of artificial intelligence, and their potential as biomarkers.

Main Methods:

  • Literature review of circRNA research in the cardiovascular system.
  • Synthesis of information on circRNA biogenesis and function.
  • Exploration of current and emerging research methodologies, including AI applications.

Main Results:

  • CircRNAs play significant roles in cardiovascular regulation and disease development.
  • Understanding circRNA expression and function is critical for cardiovascular research.
  • Artificial intelligence offers promising avenues for advancing circRNA studies.

Conclusions:

  • CircRNAs are vital players in cardiovascular biology and disease.
  • Further research into circRNAs, aided by AI, can uncover novel therapeutic targets and biomarkers.
  • CircRNAs hold significant potential as diagnostic and prognostic biomarkers for cardiovascular diseases.