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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
Published on: October 21, 2022
Molecular functions and specific roles of circRNAs in the cardiovascular system
Lesca M Holdt1, Alexander Kohlmaier1, Daniel Teupser1
1Institute of Laboratory Medicine, University Hospital, LMU Munich, Germany.
Insights
Circular RNAs (circRNAs) are key regulators in gene expression and cardiovascular disease. This review covers circRNA roles, biogenesis, and interactions in heart conditions, highlighting their biomarker potential.
Area of Science:
- Molecular Biology
- Genetics
- Cardiovascular Research
Background:
- Long noncoding RNAs (lncRNAs) encompass circular RNAs (circRNAs), novel regulatory molecules.
- circRNAs are increasingly recognized for their roles in gene expression control.
- Cardiovascular diseases (CVDs) represent a significant global health burden.
Purpose of the Study:
- To review the current understanding of circRNAs in cardiovascular disease.
- To explore circRNAs as effector molecules and biomarkers in cardiovascular pathophysiology.
- To contextualize circRNA functions within their biogenesis and molecular interactions.
Main Methods:
- Literature review of existing research on circRNAs and cardiovascular disease.
- Synthesis of data on circRNA association with various cardiovascular conditions.
- Analysis of circRNA biogenesis pathways and interaction networks (DNA, RNA, proteins).
Main Results:
- circRNAs are implicated in diverse cardiovascular diseases.
- circRNAs function as intracellular effectors in cardiovascular tissue pathophysiology.
- circRNAs show promise as reliable cardiovascular biomarkers.
Conclusions:
- circRNAs are significant players in cardiovascular disease pathogenesis and progression.
- Understanding circRNA biogenesis and interactions is crucial for therapeutic development.
- circRNAs represent a valuable area for future cardiovascular research and clinical application.
Abstract:
As part of the superfamily of long noncoding RNAs, circular RNAs (circRNAs) are emerging as a new type of regulatory molecules that partake in gene expression control. Here, we review the current knowledge about circRNAs in cardiovascular disease. CircRNAs are not only associated with different types of cardiovascular disease, but they have also been identified as intracellular effector molecules for pathophysiological changes in cardiovascular tissues, and as cardiovascular biomarkers. This evidence is put in the context of the current understanding of general circRNA biogenesis and of known interactions of circRNAs with DNA, RNA, and proteins.
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