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Strategies for Predicting Response to Checkpoint Inhibitors
Roberta Zappasodi1,2, Jedd D Wolchok1,2,3,4, Taha Merghoub5,6,7
1Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Current Hematologic Malignancy Reports
|August 31, 2018
Summary
Identifying biomarkers for immune checkpoint blockade response is crucial for patient treatment. This review categorizes biomarkers into tumor-intrinsic, immune microenvironmental, host-related, and dynamic factors to predict therapy success.
Area of Science:
- Oncology
- Immunology
- Biomarker Discovery
Background:
- Immune checkpoint blockade (ICB) therapies have shown success in various cancers.
- However, many patients exhibit primary resistance or develop acquired resistance to ICBs.
- Understanding the molecular basis of ICB response is essential for personalized treatment strategies.
Purpose of the Study:
- To review and categorize biomarkers associated with response to immune checkpoint blockade.
- To provide a framework for assessing biomarkers to predict clinical outcomes.
- To enhance the rational and personalized application of ICB therapies.
Main Methods:
- Systematic review and classification of existing biomarkers for ICB activity.
- Categorization into four major groups: tumor-intrinsic, immune microenvironmental, host-related, and dynamic factors.
- Proposed model for assessing baseline and dynamic biomarkers in relation to patient outcomes.
Main Results:
- Identified and classified key biomarkers influencing ICB response.
- Highlighted the importance of integrating diverse biomarker types for accurate prediction.
- Emphasized the role of both baseline and dynamic factors in determining treatment efficacy.
Conclusions:
- Biomarker-driven stratification is critical for optimizing ICB therapy.
- A comprehensive understanding of tumor-immune interactions and dynamics can guide personalized treatment.
- Further research and systematic biomarker assessment will improve patient outcomes in cancer immunotherapy.
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