Fenofibrate and Dyslipidemia: Still a Place in Therapy?

Nicola Tarantino1, Francesco Santoro1,2, Michele Correale3

  • 1Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.

Drugs
|August 31, 2018
PubMed

Insights

Fenofibrate may offer additional cardiovascular protection beyond statins for patients with atherogenic dyslipidemia. This review examines current evidence on fenofibrate

Area of Science:

  • Cardiology
  • Endocrinology
  • Pharmacology

Background:

  • Dyslipidemia is a key cardiovascular risk factor.
  • Statin therapy is the primary treatment.
  • Uncertainty exists regarding the use of fibrates.

Purpose of the Study:

  • To review current evidence on fenofibrate.
  • To interpret recent studies on fenofibrate's role in cardiovascular risk.
  • To address the use of peroxisome proliferator-activated receptor agonists.

Main Methods:

  • Literature review of recent studies on fenofibrate.
  • Analysis of clinical trial data.
  • Interpretation of evidence regarding residual cardiovascular risk.

Main Results:

  • Guidelines recommend peroxisome proliferator-activated receptor agonists for specific cases.
  • Fenofibrate shows potential as complementary therapy for residual cardiovascular risk.
  • Recent observations support fenofibrate's efficacy.

Conclusions:

  • Fenofibrate may be a valuable option for managing atherogenic dyslipidemia.
  • Further interpretation of fenofibrate's role in reducing residual cardiovascular risk is warranted.
  • Evidence supports fenofibrate's complementary role in cardiovascular risk management.

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