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A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse
Published on: October 24, 2017
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Eculizumab in pregnancy: a narrative overview
Laura Sarno1, Antonella Tufano2, Giuseppe Maria Maruotti1
1Department of Neurosciences, Dentistry and Reproductive Sciences, University Federico II, Naples, Italy.
Journal of Nephrology
|August 31, 2018
Summary
Eculizumab may be safe for treating paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and HELLP syndrome during pregnancy. Limited data suggest minimal risk to newborns, but further research is needed.
Area of Science:
- Hematology
- Immunology
- Obstetrics
Background:
- Pregnancy poses risks for patients with paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and HELLP syndrome.
- These conditions can lead to serious complications, often discouraging pregnancy.
Purpose of the Study:
- To review the current evidence on the safety and efficacy of eculizumab during pregnancy for women with PNH, aHUS, and HELLP syndrome.
- To assess the potential risks and benefits of eculizumab treatment in pregnant patients.
Main Methods:
- This study is a narrative overview.
- It summarizes existing data on eculizumab use in pregnant women with PNH, aHUS, and HELLP syndrome.
Main Results:
- Eculizumab is not detected in breast milk.
- Umbilical cord blood levels of eculizumab are insufficient to impact neonatal complement concentrations.
- The drug may be considered safe for use during pregnancy.
Conclusions:
- Eculizumab shows potential as a safe treatment option for PNH, aHUS, and HELLP syndrome during pregnancy.
- Despite promising findings, limited data necessitate caution, as risks to mother and fetus cannot be entirely excluded.
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