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Related Experiment Video

Updated: Feb 6, 2026

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Status epilepticus in the elderly.

Ilo E Leppik1

  • 1Department of Pharmacy and Neurology, University of Minnesota, Minneapolis, Minnesota.

Epilepsia
|August 31, 2018
PubMed
Summary
This summary is machine-generated.

Status epilepticus (SE) disproportionately affects the elderly, leading to severe consequences and high mortality. Current treatments for SE are not age-specific, highlighting the need for etiology-targeted therapies.

Keywords:
convulsive status epilepticuselderlynonconvulsive status epilepticusstatus epilepticus

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Area of Science:

  • Neurology
  • Geriatrics
  • Emergency Medicine

Background:

  • Status epilepticus (SE) incidence is highest in children and the elderly (≥60 years).
  • Elderly individuals face more severe seizure consequences due to general health status.
  • SE incidence increases with age, with the oldest groups (80+) showing the highest rates.

Purpose of the Study:

  • To analyze the incidence, causes, and outcomes of SE in the elderly.
  • To evaluate current SE treatment protocols for the elderly population.
  • To identify the need for age- and etiology-specific SE treatments.

Main Methods:

  • Review of SE incidence data across different age groups.
  • Analysis of common causes of SE in the elderly, focusing on stroke and hypoxia.
  • Examination of SE mortality rates and contributing factors, including age and etiology.
  • Assessment of current pharmacological interventions for SE.

Main Results:

  • SE incidence rises significantly with advancing age.
  • Acute symptomatic causes, particularly stroke and hypoxia, are most frequent in the elderly.
  • SE mortality is high, especially in cases of anoxia (over 80%).
  • Current SE treatments are standard antiseizure drugs, not tailored for age or specific causes.

Conclusions:

  • The aging brain and body may contribute to poorer SE outcomes.
  • Existing SE treatments lack evidence-based support for elderly-specific care (Axis 2 and 4).
  • Development of etiology-specific treatments is crucial for improving SE outcomes in all age groups, especially the elderly.