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The Risk of Gout Among Patients With Sleep Apnea: A Matched Cohort Study
Milica Blagojevic-Bucknall1, Christian Mallen1, Sara Muller1
1Keele University, Arthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Services, Newcastle-under-Lyme, Staffordshire, UK.
Arthritis & Rheumatology (Hoboken, N.J.)
|August 31, 2018
Summary
Obstructive sleep apnea (OSA) increases gout risk. Patients with OSA had a 42% higher chance of developing gout, with risk peaking within two years, varying by BMI.
Area of Science:
- Sleep Medicine
- Rheumatology
- Epidemiology
Background:
- Obstructive sleep apnea (OSA) is linked to various health issues.
- Gout is a common inflammatory arthritis.
- The relationship between OSA and gout risk requires further investigation.
Purpose of the Study:
- To determine if individuals with OSA have a higher likelihood of developing gout.
- To examine the short-term and long-term risks of gout in OSA patients.
- To analyze gout risk based on body mass index (BMI) categories.
Main Methods:
- A retrospective cohort study utilized the UK Clinical Practice Research Datalink.
- 15,879 OSA patients were matched with 63,296 controls (age, sex, practice).
- Cox regression analysis adjusted for health, lifestyle, and comorbidities; follow-up to 2015.
Main Results:
- OSA patients showed a 42% increased risk of developing gout (adjusted HR 1.42).
- The highest risk for gout was observed 1-2 years post-diagnosis in OSA patients.
- Peak gout incidence varied by BMI, with significant risks persisting in overweight and obese individuals.
Conclusions:
- Individuals with OSA face a sustained elevated risk of developing gout.
- The timing of peak gout incidence following OSA diagnosis is influenced by BMI.
- Further research into the mechanisms linking OSA and gout is warranted.
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