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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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[Mitochondrial disorders in multiple sclerosis].

I A Kazantseva1, S V Kotov1, E V Borodataya1

  • 1Moscow Regional Research and Clinical Institute, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|August 31, 2018
PubMed
Summary

Mitochondrial dysfunction, indicated by decreased enzyme activity and increased lactate, is present in multiple sclerosis (MS) patients. Energotrophic drugs like carnicetin and coenzyme Q10 may benefit MS treatment.

Keywords:
carnicetinidebenonemitochondriamultiple sclerosis

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Area of Science:

  • Biochemistry
  • Neuroscience
  • Cell Biology

Background:

  • Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system.
  • Mitochondrial dysfunction is increasingly recognized as a contributing factor in neurodegenerative diseases like MS.

Purpose of the Study:

  • To investigate mitochondrial dysfunction in patients with multiple sclerosis (MS).
  • To assess the activity of key mitochondrial enzymes and blood lactate levels in MS patients.

Main Methods:

  • Cytochemical analysis of peripheral blood lymphocytes from 14 MS patients and 23 healthy controls.
  • Measurement of lactate dehydrogenase (LDH), glutamate dehydrogenase (GDH), alpha-glycerophosphate dehydrogenase (α-GPDH), and succinate dehydrogenase activities.
  • Quantification of blood lactate levels before and after carbohydrate loading.

Main Results:

  • Reduced activity of α-GPDH (62.5%), GDH (100%), and LDH (71.4%) was observed in MS patients.
  • Elevated blood lactate levels were found in a significant portion of MS patients, particularly after carbohydrate loading.
  • Variations in enzyme activity suggested decompensation of mitochondrial function in the majority of MS patients.

Conclusions:

  • The findings indicate significant mitochondrial dysfunction in multiple sclerosis.
  • The results support the potential therapeutic benefit of energotrophic drugs, such as carnicetin and coenzyme Q10 (idebenone), for MS management.