[Issues of the current terminology in multiple sclerosis]

Area of Science:

• Neurology
• Clinical Neuroscience
• Medical Terminology

Background:

• Multiple Sclerosis (MS) diagnosis and management rely on precise terminology.
• Evolving understanding of MS necessitates updated clinical language.
• Current terms for MS signs, courses, and treatment efficacy require clarification.

Purpose of the Study:

• To review and discuss new and existing terminology used in multiple sclerosis.
• To standardize terms related to MS diagnosis, disease course, and therapeutic outcomes.
• To clarify classifications of MS therapies, including escalation, induction, and immune reconstitution.

Main Methods:

• Literature review of current neurological terminology in multiple sclerosis.
• Analysis of terms related to MS diagnosis, relapse, and disease course.
• Discussion of therapeutic concepts such as No Evidence of Disease Activity (NEDA) and treatment strategies (TIR, TME).

Main Results:

• Identified ambiguity in terms like 'definite' MS, 'MS signs', and 'optic neuritis'.
• Highlighted the need for standardized definitions for MS relapse, exacerbation, and disease course.
• Presented a classification of MS therapies including escalation, induction, therapy of immune reconstitution (TIR), and therapy of maintenance/escalation (TME).

Conclusions:

• Standardized terminology is crucial for accurate MS diagnosis and effective communication.
• Clear definitions of therapeutic goals (e.g., NEDA, NEP, NEPAD) enhance treatment monitoring.
• A structured approach to classifying MS therapies aids in treatment selection and management.