Speckle noise reduction for digital holographic images using multi-scale convolutional neural networks
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Updated: Feb 6, 2026

Evaluation and Manipulation of Neural Activity Using Two-Photon Holographic Microscopy
Published on: September 16, 2022
Abstract:
In this Letter, we propose a fast speckle noise reduction method with only a single reconstructed image based on convolutional neural networks. The proposed network has multi-sized kernels that can capture the speckle noise component effectively from digital holographic images. For robust noise reduction performance, the network is trained with a large noisy image dataset that has object-dependent noise and a wide range of noise levels. The experimental results show the fast, robust, and outstanding speckle noise reduction performance of the proposed approach.
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