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Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
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Related Experiment Video

Updated: Feb 6, 2026

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
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White Matter Degeneration after Ischemic Stroke: A Longitudinal Diffusion Tensor Imaging Study.

Milanka M Visser1,2, Nawaf Yassi3,4, Bruce C V Campbell3,4

  • 1School of Medicine and Public Health, Faculty of Health and Medicine, University of Newcastle, Callaghan, New South Wales, Australia.

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
|August 31, 2018
PubMed
Summary
This summary is machine-generated.

White matter degeneration after ischemic stroke appears localized to specific brain regions, not a global phenomenon. This study used diffusion tensor imaging to track changes over time in stroke patients.

Keywords:
Ischemic strokeNational Institutes of Health Stroke Scalediffusion tensor imagingwhite matter degeneration

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Area of Science:

  • Neuroimaging
  • Stroke Research
  • White Matter Integrity

Background:

  • Gray matter and subcortical degeneration post-stroke is known.
  • White matter degeneration patterns after stroke remain poorly understood.
  • Uncertainty exists regarding global versus localized white matter changes.

Purpose of the Study:

  • To investigate white matter degeneration patterns after ischemic stroke.
  • To determine if degeneration is global or localized to specific brain areas.

Main Methods:

  • Prospective study of acute ischemic stroke patients.
  • Collected National Institutes of Health Stroke Scale (NIHSS) scores and diffusion tensor imaging (DTI) at baseline, 1, and 3 months.
  • Analyzed DTI parameters in specific regions of interest (ROIs) and assessed changes over time using linear mixed-effect modeling.

Main Results:

  • Seventeen patients (mean age 71) were included.
  • Observed significant white matter changes over time in visual cortices, contralesional motor/premotor cortex, and superior temporal gyrus.
  • Localized changes were seen in ipsilesional motor cortex and inferior parietal lobule in patients with relevant NIHSS scores; no global changes were detected.

Conclusions:

  • White matter changes following ischemic stroke are likely localized.
  • Findings suggest specific brain regions are more susceptible to white matter degeneration post-stroke.
  • DTI can identify localized white matter alterations over time.