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Expanding the indication of endoscopic papillectomy for T1a ampullary carcinoma

Kenjiro Yamamoto¹, Takao Itoi¹, Atsushi Sofuni¹

¹Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.

Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society

|August 31, 2018

Abstract

Background And Aim:

Endoscopic papillectomy (EP) has been attempted not only for benign lesions but also for early ampullary carcinoma (AC). However, there is still no sufficient evidence or consensus regarding the effectiveness of EP for early AC. Herein, we evaluated the expanding indication of EP for early AC.

Methods:

Between May 1999 and December 2016, 177 patients were diagnosed with ampullary tumor before undergoing EP, and their clinical and histopathological data were analyzed retrospectively.

Results:

There were 27 Tis-T1a AC patients and four T1b AC patients who underwent EP. Mean tumor size was 14.1 mm for Tis-T1a AC and 17.0 mm for T1b AC. For the histological grade, 50% (2/4) of T1b AC were moderately differentiated, whereas 96.3% (26/27) of Tis-T1a AC were well differentiated and papillary. For lymphovascular invasion, one (25%) occurred in T1b AC but none occurred in Tis-T1a AC. There was no AC recurrence from the date of EP until a maximum of 5 years (Tis-T1a: mean period 48.5 months [5-60]; T1b: mean period 26.5 months [3-60]).

Conclusions:

Endoscopic papillectomy is useful and reliable for the curative treatment of T1a AC. Large-scale prospective studies with long-term follow up are needed.

Keywords:

ampullary carcinoma ampullary tumor curative treatment endoscopic papillectomy indication

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