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Four new C-benzyl flavonoids from the fruit of Uvaria cherrevensis
Chiramet Auranwiwat1, Roonglawan Rattanajak2, Sumalee Kamchonwongpaisan2
1Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Chiang Mai University, Sutep, Muang, Chiang Mai 50200, Thailand; The Graduate School, Chiang Mai University, Chiang Mai 50200, Thailand; School of Chemistry, University of Wollongong, Wollongong, New South Wales 2522, Australia.
Abstract:
The phytochemical investigation of the fruit extracts of Uvaria cherrevensis led to the isolation and characterization of four new C-benzyl flavonoids; cherrevenones A-D (1-4) together with 11 known compounds. The isolated compounds were characterized using spectroscopic techniques. Compounds 1, 3, 5 and 11 showed moderate inhibitory activities against the P. falciparum strains TM4/8.2 and K1CB1 with IC50 values ranging from 21.0 ± 3.10 - 33.7 ± 7.69 and 21.0 ± 5.44 - 43.5 ± 11.9 μM, respectively. Compounds 1, 2, 5, 10 and 11 exhibited strong cytotoxic activities against KB cells with IC50 values ranging from 0.60 ± 0.17 - 4.91 ± 2.69 μM which were similar to their cytotoxic activities found against Vero cells, except for compound 5, which was non-toxic to Vero cells.
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