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Related Experiment Video

Updated: Feb 5, 2026

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Chemokine Subversion by Human Herpesviruses.

Sergio M Pontejo1, Philip M Murphy1, James E Pease2

  • 1Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Journal of Innate Immunity
|August 31, 2018
PubMed
Summary
This summary is machine-generated.

Herpesviruses encode immune evasion proteins like chemokines and chemokine receptors. These viral components manipulate host cells and immune responses to establish a proviral state.

Keywords:
Chemokine receptorsChemokinesViral infection

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Area of Science:

  • Virology
  • Immunology
  • Molecular Biology

Background:

  • Viruses employ diverse molecular strategies to manipulate host immune responses.
  • Herpesviruses are known to encode proteins that interfere with host immunity.

Purpose of the Study:

  • To review the roles of human herpesvirus-encoded chemokines, chemokine receptors, and chemokine-binding proteins.
  • To elucidate how these viral components contribute to establishing a proviral state.

Main Methods:

  • Literature review of existing research on herpesvirus immune modulation.
  • Analysis of the functions of viral chemokine homologs and binding proteins.

Main Results:

  • Herpesviruses encode functional chemokine and chemokine receptor homologs.
  • Secreted viral chemokine-binding proteins possess unique structures.
  • These viral components attract target cells, block leukocyte migration, and modulate gene expression.

Conclusions:

  • Human herpesvirus chemokines, receptors, and binding proteins are key viral factors.
  • These factors collectively shape a proviral environment within the host.