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The risk profile of rhegmatogenous retinal detachment before and after using a fluoroquinolone: a 12 year nationwide

Ju-Young Shin¹, Sohyun Jeong¹, Ha-Lim Jeon¹

¹School of Pharmacy, Sungkyunkwan University, Suwon, South Korea.

The Journal of Antimicrobial Chemotherapy

|August 31, 2018

Abstract

Objectives:

To determine whether or not fluoroquinolone use increases the incidence of retinal detachment.

Design:

Self-controlled case series analysis.

Participants:

Participants were identified using the South Korean National Health Insurance Database between 1 January 2004 and 31 December 2015. A total of 15 134 patients who experienced rhegmatogenous retinal detachment (RRD) with at least one prescription of a fluoroquinolone were included.

Methods:

Incidence rate ratios (IRRs) and their 95% CIs were calculated using conditional Poisson regression. The main outcome measure was a recorded diagnosis of RRD (ICD-10: H33.0) with a claim for the surgical code for RRD.

Results:

We found an increased risk of retinal detachment in the first 1-30 days following the initiation of fluoroquinolone therapy (IRR 1.85; 95% CI 1.71-1.95), which rose for the 31-60 days period (IRR 2.05; 95% CI 1.43-2.95) but remained constant after more than 60 days (IRR 1.25; 95% CI 0.75-2.10). However, the elevated risk was also found in the 1-30 day period prior to the initiation of fluoroquinolone therapy (IRR 1.58; 95% CI 1.49-1.68) and also 31-60 days before medication use (IRR 1.11; 95% CI 1.03-1.19).

Conclusions:

Our case-based study indicated that the risk after fluoroquinolone exposure doubled; however, the risk profile before and after fluoroquinolone use means that the association between fluoroquinolone use and retinal detachment might not be a causal relationship.

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