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Biasing Enantiomorph Formation via Geometric Confinement: Nanocorrals for Chiral Induction at the Liquid-Solid
Johannes Seibel1, Lander Verstraete1, Brandon E Hirsch1
1Department of Chemistry, Division of Molecular Imaging and Photonics , KU Leuven , Celestijnenlaan 200F , B-3001 Leuven , Belgium.
Journal of the American Chemical Society
|September 1, 2018
Summary
Scanning probe lithography creates nanocorrals on graphite surfaces to control molecular assembly. This technique induces a chiral bias, enabling selective self-assembly of molecules on achiral surfaces.
Area of Science:
- Surface science
- Nanotechnology
- Chiral chemistry
Background:
- Molecular self-assembly is crucial for creating ordered structures.
- Controlling chirality in molecular assembly on surfaces is challenging.
- Achiral surfaces typically result in racemic mixtures.
Purpose of the Study:
- To develop a method for inducing chiral bias in molecular assembly.
- To utilize scanning probe lithography for creating nanoscale chiral environments.
- To investigate the enantiomorphic assembly of prochiral molecules.
Main Methods:
- Fabrication of nanocorrals using scanning probe lithography on modified graphite.
- Covalent modification of graphite surfaces.
- Analysis of molecular assembly at the liquid/graphite interface.
Main Results:
- Nanocorrals successfully induced a chiral bias in molecular assembly.
- The orientation of nanocorrals determined the handedness of the molecular assembly.
- Chiral bias was achieved on an achiral surface solely through nanocorral fabrication.
Conclusions:
- Scanning probe lithography offers precise control over surface chirality.
- Nanocorrals can direct enantiomorphic assembly of prochiral molecules.
- This method provides a novel route to create chiral structures on demand.
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