Related Experiment Video

Updated: Feb 5, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

4.3K

Exercise Training for Patients With Hypertrophic Cardiomyopathy: JACC Review Topic of the Week

Katrin A Dias1, Mark S Link2, Benjamin D Levine1

  • 1Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, Texas; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.

Journal of the American College of Cardiology
|September 1, 2018
PubMed

Insights

Current guidelines advise against high-intensity exercise for hypertrophic cardiomyopathy (HCM) patients. This review explores if higher intensity exercise could safely improve cardiorespiratory fitness in HCM, potentially outweighing risks.

Area of Science:

  • Cardiology
  • Exercise Physiology
  • Genetics

Background:

  • Current guidelines for hypertrophic cardiomyopathy (HCM) restrict high-intensity exercise due to sudden cardiac death risks.
  • Inactivity is prevalent in HCM patients, often stemming from fear of exercise-induced adverse events.
  • Moderate-intensity exercise in HCM shows modest gains in cardiorespiratory fitness and may be safe.

Purpose of the Study:

  • To review the evidence on the safety and efficacy of various exercise intensities in HCM patients.
  • To explore the potential benefits of high-intensity exercise for improving cardiorespiratory fitness in HCM.
  • To consider new strategies for enhancing fitness in individuals with HCM.

Main Methods:

  • Literature review of studies on exercise training in hypertrophic cardiomyopathy.
  • Analysis of data from trials like RESET-HCM regarding exercise intensity and outcomes.
  • Examination of the relationship between cardiorespiratory fitness and cardiovascular mortality in chronic disease populations.

Main Results:

  • Moderate-intensity exercise in HCM is generally safe but yields limited improvements in cardiorespiratory fitness.
  • High-intensity exercise is a potent stimulus for cardiorespiratory fitness gains in other chronic conditions.
  • Potential benefits of improved fitness in HCM may surpass theoretical exercise risks.

Conclusions:

  • Re-evaluation of exercise guidelines for HCM may be warranted, considering potential benefits of higher intensity training.
  • Improved cardiorespiratory fitness through exercise could reduce cardiovascular mortality risk in HCM.
  • Further research into safe and effective exercise strategies for HCM is needed.

Keywords:
arrhythmiacardiorespiratory fitnessexercise guidelineshigh-intensity trainingsudden cardiac death

More Related Videos

Setup and Execution Of the Blindfolded Code Training Exercise05:25

Setup and Execution Of the Blindfolded Code Training Exercise

Published on: March 29, 2019

10.0K
A Swimming-Induced Zebrafish Exercise Apparatus for Versatile Training Approaches10:34

A Swimming-Induced Zebrafish Exercise Apparatus for Versatile Training Approaches

Published on: October 18, 2024

1.8K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
496
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
575
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
552
Review and Preview01:10

Review and Preview

In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview01:13

Review and Preview

Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.5K
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
459